To interrupt the SARS-CoV-2 transmission chain, Ultraviolet-C (UVC) irradiation has emerged as a potential disinfection tool to aid in blocking the spread of coronaviruses. While conventional 254-nm UVC mercury lamps have been used for disinfection purposes, other UVC wavelengths have emerged as attractive alternatives but a direct comparison has not been made with the inherent mechanisms unclear. Our results indicate that 277-nm UVC LED lamps are most effective in viral inactivation, followed by 222-nm far UVC and 254-nm UVC mercury lamp. While UVC mercury lamp is more effective in degrading viral genomic content compared to 277-nm UVC LED, the latter results in a pronounced photo-degradation of spike proteins which potentially contributed to the higher efficacy of coronavirus inactivation. Hence, UV inactivation of coronaviruses by 277–nm UV C LED irradiation constitutes a more promising method for disinfection.

Source : ResearchGate